Abaphandi bafumanise ukuba i-metabolte eyintloko ye-thta isekwe kwidatha evela kwiimodeli zemouse. Idatha entsha yoPhando ibonisa ukuba i-thc metabolite ye-thta ye-thtang emuren kunye negazi isenokusebenza kwaye isebenza njenge-thc, ukuba ayikho ngaphezulu. Oku kufumanisa oku kuphakamisa imibuzo emininzi kunokuba iphendulwe. Ngokutsho kophando lwakutsha nje olupapashwe kwijenali ye-pharmacology kunye novavanyo lwe-11-Hydroxy-thc (i-11-oh-thc), inesipolo esilinganayo okanye i-Delta-9 thc).
Isifundo, isihloko esithi "Ukudakulelwa" ukulingana kwe-11-Delta-9-thc (11-th-9-th-9-thc) Iyonkalelanisa umsebenzi. Kuyaziwa ukuba i-thc iqhekeza kwaye ivelise imilinganiselo enokubangela umdla enomdla xa ibolekwe emzimbeni nasekuwonyeni komzimba womntu. "Kolu phando, sizimisele ukuba i-metabolte eyintloko ye-thta, i-11-Owu-thc, ibonisa imisebenzi elinganayo okanye enkulu kune-thnc yemodeli ye-cannabinoid xa ilawulwa ngokuthe ngqo kwiindlela zemouse, i-pharmaconkinetics," i-pharmacodinetics, ". "Ezi datha zibonelela ngokuqonda ezibalulekileyo kwimisebenzi ye-thc metablid, yazisa uphando kwimodeli ye-cannabinaid, kunye nemodeli indlela i-thc kunye ne-metabolism ichaphazela ngayo ukusetyenziswa kwe-cannabis."
Olu phando lwenziwe liqela ukusuka eSaskatchewan, Canada, kubandakanya neat Zagzoog, Kenzie Hanes, Jones, Maria-Maria Slondakova, Robert B. I-Robert B. Ladirie. Kwilingo, abaphandi banamafutha amanqakwane nge-11-thdroxy-th kwaye baqwalasele kwaye bafunda imiphumo yale thc metabolite xa kuthelekiswa nomzali ongumzali, i-Delta-9 thc.
Abaphandi baphinde baphawule:
Ngenxa yoko, isifundo sicebisa ukuba i-thc metabolite 11-Owu-th inokuthi idlale indima ebalulekileyo kwimisebenzi ye-cannabis ye-cannabis. Ukuqonda umsebenzi wayo xa iqhutywa ngokuthe ngqo iza kunceda ekupheliseni izifundo zexesha elizayo. Ingxelo ikhankanya ukuba i-11-Owe-thc yenye yezona ndlela zimbini zeMetablites emva kokuselwa kwe-cannabis, enye i-11-ne-15-i-9-thcy-thc, i-carboxy-thc ixesha elide.
Ngokwamaziko e-US ukuze alawule izifo kunye nokuthintela (i-CDC), kwangethuba, kwasekupheleni kwe-19-doxta-9-thc-9-thc-9-thc-9-thc-9-thc, eyiyona nto isebenzayo kwi-cannabis.
Ingxelo ichaza ukuba nangona i-cannabis etshatileyo ivelisa iziphumo ngokukhawuleza kunokuchitha i-cannabis edds, isixa se-11-oH-thc esiveliswe ngo-11-Owe-thc esine-ADC sikhulu kunoko iintyatyambo zokutshaya. Le ngxelo yenye yesizathu sokuba ukutya ukutya okungena-unnabis kunokuba yinto yengqondo kwaye ibangele ukuba kungazi nto.
I-thc metabolites kunye novavanyo lweziyobisi
Ubungqina bubonisa ukuba i-cannabis ichaphazela abasebenzisi ngokwahlukileyo kuxhomekeka kwindlela yolawulo. Isifundo sama-2021 sapapashwa kwijenali esisigxina sibonisa ukuba iziphumo zokuchitha i-cannabis zinkulu kunezo zokutshaya ngenxa ye-metabolism ye-11-oh-thc.
"I-biaaaiffiy ye-thc ngokusebenzisa i-vaporization yi-10% ukuya kwi-35%," babhala abaphandi. "Emva kokufika, i-thc ingena esibindini, apho uninzi lwayo luphelisiwe okanye lwenziwe kwi-11-oh-thc okanye i-biehc okanye i-biah-ths, i-thc-ths, i-Th. i-Thc ingena kwizicubu ezinamafutha. Ngokwesiqhelo, i Iplasma isiqingatha-ubomi be-thc ngokwase-thc sine-1 ukuya kwiintsuku ezi-3, ngelixa singabasebenzisi abanganyangekiyo, kunokuba njalo kwiintsuku ezi-5 ukuya kwezili-13. "
Izifundo zibonisa ukuba ixesha elide emva kokuba i-cannabis yengqondo inxibile, i-thc metabolites njenge-11-oH-th-th-thc ingahlala egazini kunye nomchamo wamaxesha amaninzi. Oku kubeka imiceli mngeni yeendlela ezisemgangathweni zokuvavanya ukuba ngaba ngabaqhubi kunye neembaleki ziyaphazamiseka ngenxa yokusetyenziswa kwe-cannabis. Umzekelo, abaphandi base-Australia bebezama ukumisela ixesha isakhelo sexesha apho i-cannabis ingakwazi ukwenza umsebenzi wokuqhuba. Kwimeko enye, uThomas R. Arkell, uDanielle McCarregon, kunye ne-IAin ScCregor kwiphulo leYunivesithi kwiDyunivesithi yaseSydney efundeka i-cannabis kumandla okuqhuba. Iqela lagqiba ekubeni i-cannabis ithobe amandla okuqhuba iiyure ezininzi emva kokutshaya, kodwa ezi zithintelo ziphela ngaphambi kokuba i-thc metabolites iconjululwe emzimbeni kangangeeveki okanye kwiinyanga.
"Izigulana ezisebenzisa iimveliso ezinazo ze-thc kufuneka ziphephe ukuqhuba kunye neminye imisebenzi enolwazi (umz. Nokuba izigulana aziziva zimangalela, zisenokuvavanya ukuba zilungile kwi-thc. Ngapha koko, abaguli be-cannabis baseCannabis ngoku bangaxolelwanga ekuvavanyweni kweziyobisi nesemo yeziyobisi. "
Olu phando lutsha kwi-11-Owu-th lubonisa ukuba kufuneke izifundo ezingakumbi ukuze kuqondakale indlela i-thtabolites ichaphazele ngayo umzimba womntu. Ngamaxesha aqhubekayo kuphela esinokubutyhila ngokupheleleyo iimfihlo zala maqhinga ahlukileyo.
Ixesha lasemva kwexesha: Mar-21 ukuya ku-525