Abaphandi bafumanise ukuba i-metabolite yokuqala ye-THC ihlala inamandla ngokusekwe kwidatha evela kwiimodeli zemouse. Idatha yophando olutsha lucebisa ukuba eyona metabolite ye-THC ehlala kumchamo kunye negazi isenokuthi isebenze kwaye isebenze njenge-THC, ukuba akunjalo. Esi siphumo esitsha siphakamisa imibuzo emininzi kuneempendulo. Ngokophononongo lwakutsha nje olupapashwe kwiJenali ye-Pharmacology kunye ne-Experimental Therapeutics, i-psychoactive metabolite ye-THC, i-11-hydroxy-THC (11-OH-THC), inamandla alinganayo okanye amakhulu okusebenza kwengqondo kune-THC (Delta-9 THC).
Uphononongo, olunesihloko esithi "I-Intoxication Equivalence ye-11-Hydroxy-Delta-9-THC (11-OH-THC) enxulumene ne-Delta-9-THC," ibonisa indlela i-THC ye-metabolites igcina ngayo umsebenzi. Kuyaziwa ukuba i-THC idiliza kwaye ivelise iikhompawundi ezintsha ezinomdla xa i-decarboxylates kwaye isebenza emzimbeni womntu. "Kolu phononongo, sinqume ukuba i-metabolite ephambili ye-THC, i-11-OH-THC, ibonisa umsebenzi olinganayo okanye omkhulu kune-THC kwimodeli yomsebenzi we-cannabinoid yegundane xa ilawulwa ngokuthe ngqo, nokuba iqwalasela ukungafani kwiindlela zokulawula, isondo, i-pharmacokinetics, kunye ne-pharmacodynamics," isifundo sithi. "Ezi datha zibonelela ngolwazi olubalulekileyo kwimisebenzi yebhayoloji ye-THC metabolites, yazisa uphando lwe-cannabinoid lwexesha elizayo, kwaye ibonise indlela i-THC ethatha ngayo kunye nemetabolism ekuchaphazela ngayo ukusetyenziswa kwe-cannabis yabantu."
Olu phando lwenziwe liqela laseSaskatchewan, eCanada, kuquka u-Ayat Zagzoog, uKenzie Halter, u-Alayna M. Jones, uNicole Bannatyne, uJoshua Cline, u-Alexis Wilcox, u-Anna-Maria Smolyakova, noRobert B. Laprairie. Kuvavanyo, abaphandi batofa iimpuku zamadoda nge-11-hydroxy-THC kwaye bajonga kwaye bafunda iziphumo zale metabolite ye-THC xa kuthelekiswa nekhompawundi yomzali wayo, iDelta-9 THC.
Abaphandi bahlabela mgama bathi: "Ezi datha zibonisa ukuba kuvavanyo lwe-tail-flick yokuqonda intlungu, umsebenzi we-11-OH-THC yi-153% ye-THC, kunye novavanyo lwe-catalepsy, umsebenzi we-11-OH-THC ngu-78% we-THC. Ngoko ke, kwanokuqwalasela ukungafani kwe-pharmacokinetic i-comparable-comparable okanye i-THC11 yomzali, i-pharmacokinetic i-comparable I-THC.
Ke, uphando lucebisa ukuba i-THC imetabolite 11-OH-THC inokudlala indima ebalulekileyo kwimisebenzi yebhayoloji ye-cannabis. Ukuqonda umsebenzi wayo xa ilawulwa ngokuthe ngqo kuya kunceda ukucacisa ikamva lezilwanyana kunye nezifundo zabantu. Ingxelo ikhankanya ukuba i-11-OH-THC yenye yee-metabolites ezimbini eziphambili ezenziwe emva kokusetyenziswa kwe-cannabis, enye i-11-nor-9-carboxy-THC, engeyiyo ingqondo kodwa inokuhlala egazini okanye umchamo ixesha elide.
Ngokutsho kwe-US Centres for Disease Control and Prevention (CDC), ekuqaleni kwe-1980, iimvavanyo zomchamo zijolise ngokukodwa kwi-11-nor-delta-9-THC-9-carboxylic acid (9-carboxy-THC), i-metabolite ye-Delta-9-THC, eyona nto isebenzayo kwi-cannabis.
Ingxelo ibonisa ukuba nangona ukutshaya i-cannabis ngokuqhelekileyo kuvelisa iziphumo ngokukhawuleza kunokusebenzisa i-cannabis edibles, isixa se-11-OH-THC esiveliswe ngokutya sikhulu kunoko kuphuma kwiintyatyambo ze-cannabis. Ingxelo icebisa ukuba esi sesinye sezizathu zokuba ukutya okufakwe kwi-cannabis kunokuba nengqondo ngakumbi kwaye kubangele ukubhideka kwabo bangalungiselelanga.
I-THC yeMetabolites kunye noVavanyo lweziyobisi
Ubungqina bubonisa ukuba i-cannabis ichaphazela abasebenzisi ngokwahlukileyo ngokuxhomekeke kwindlela yokulawula. Uphononongo luka-2021 olupapashwe kwi-Permanent Journal lubonise ukuba iziphumo zokusetyenziswa kwe-cannabis edibles inkulu kunezo zokutshaya i-cannabis ngenxa ye-metabolism ye-11-OH-THC.
"I-bioavailability ye-THC ngokusebenzisa i-vaporization yi-10% ukuya kwi-35%," abaphandi babhala. "Emva kokuxutywa, i-THC ingena esibindini, apho ininzi yayo ikhutshwe okanye i-metabolized kwi-11-OH-THC okanye i-11-COOH-THC, kunye ne-THC eseleyo kunye ne-metabolites yayo ingena egazini. Ngokuqhelekileyo, i-plasma-half-life ye-THC kubasebenzisi ngamaxesha athile yi-1 ukuya kwiintsuku ze-3, ngelixa kubasebenzisi abangapheliyo, ingaba yi-5 ukuya kwiintsuku ze-13.
Uphononongo lubonisa ukuba ixesha elide emva kokuba iziphumo ze-psychoactive ze-cannabis ziphelile, i-THC metabolites efana ne-11-OH-THC inokuhlala egazini kunye nomchamo ixesha elide. Oku kubangela imingeni kwiindlela eziqhelekileyo zokuvavanya ukuba abaqhubi kunye neembaleki ziphazamisekile ngenxa yokusetyenziswa kwe-cannabis. Umzekelo, abaphandi baseOstreliya bebezama ukumisela ixesha elimisiweyo apho i-cannabis inokuphazamisa ukusebenza kokuqhuba. Kwesinye imeko, uThomas R. Arkell, uDanielle McCartney, kunye no-Iain S. McGregor ovela kwiLambert Initiative kwiYunivesithi yaseSydney bafunde impembelelo ye-cannabis ekuqhubeni amandla. Iqela lagqiba ukuba i-cannabis iphazamisa amandla okuqhuba iiyure ezininzi emva kokutshaya, kodwa oku kuphazamiseka kuphelile ngaphambi kokuba i-THC imetabolites icocwe egazini, kunye ne-metabolites eqhubekayo emzimbeni iiveki okanye iinyanga.
"Izigulane ezisebenzisa iimveliso ezine-THC kufuneka ziphephe ukuqhuba kunye neminye imisebenzi ekhuselekileyo yokhuseleko (umzekelo, umatshini wokusebenza), ngakumbi ngexesha lokuqala lonyango kunye neeyure eziliqela emva kwedosi nganye," ababhali babhala. "Nokuba izigulana ziziva ngathi ziphazamisekile, zisenokuvavanywa zinayo i-THC. Ngaphezu koko, abaguli be-cannabis okwangoku abakhululwa kuvavanyo lweziyobisi eziphathwayo kunye nezohlwayo ezisemthethweni."
Olu phando olutsha kwi-11-OH-THC lubonisa ukuba uphando oluninzi luyafuneka ukuze kuqondwe nzulu indlela i-THC ye-metabolites echaphazela ngayo umzimba womntu. Kuphela ngeenzame eziqhubekayo sinokuthi sityhile ngokupheleleyo iimfihlo zale mixube ekhethekileyo.
Ixesha lokuposa: Mar-21-2025