I-THC, i-CBD, i-cannabinoids, iziphumo ze-psychoactive-ukhe weva ubuncinane la magama ukuba uzama ukuqonda i-THC, i-CBD, kunye nomahluko phakathi kwabo. Mhlawumbi ukhe wadibana nenkqubo ye-endocannabinoid, i-cannabinoid receptors, kunye ne-terpenes. Kodwa yintoni yonke malunga nayo?
Ukuba ujonge indlela yokuqonda ukuba kutheni iimveliso ze-THC zikufumana phezulu kwaye iimveliso ze-CBD azikwenzi kwaye zinento yokwenza ne-endocannabinoids, wamkelekile, ukwindawo elungileyo.
I-Cannabinoids kunye nendima ye-ECS
Ukuqonda i-THC vs CBD kunye nendlela ezisichaphazela ngayo, kufuneka uqale uqonde inkqubo ye-endocannabinoid (ECS), enceda umzimba ugcine ibhalansi yokusebenza ngokusebenzisa amacandelo ayo amathathu aphambili: iamolekyu "zesithunywa", okanye i-endocannabinoids, eyenziwa yimizimba yethu; ii-receptors ezi molekyuli zibophelela kuzo; kunye neeenzymes eziziqhekezayo.
Ubuhlungu, uxinzelelo, ukutya, amandla e-metabolism, umsebenzi we-cardiovascular function, umvuzo kunye nokukhuthaza, ukuvelisa, kunye nokulala zizinto ezimbalwa zemisebenzi yomzimba echaphazela i-cannabinoids ngokusebenza kwi-ECS. Izibonelelo zempilo ezinokuthi zenzeke ze-cannabinoids zininzi kwaye ziquka ukunciphisa ukuvuvukala kunye nokulawula isicaphucaphu.
Yintoni eyenziwa yiTHC
Eyona nto ininzi kwaye iyaziwa kakhulu i-cannabinoid efunyenwe kwisityalo se-cannabis yi-tetrahydrocannabinol (THC). Ivuselela i-CB1 receptor, icandelo le-ECS kwingqondo elawula ukuxiliswa. Ukuxiliswa kwe-THC kubonakaliswe ukwandisa ukuhamba kwegazi kwi-cortex yangaphambili, ummandla wengqondo onoxanduva lokwenza izigqibo, ingqalelo, izakhono zemoto, kunye neminye imisebenzi yokulawula. Ubume obuchanekileyo beziphumo zeTHC kule misebenzi iyahluka ukusuka kumntu ukuya kumntu.
Xa i-THC ibophelela kwi-CB1 receptors, iphinda ibangele iimvakalelo zovuyo ezivela kwinkqubo yomvuzo wengqondo. I-Cannabis ivula indlela yomvuzo wengqondo, esenza sizive sonwabile, kwaye yonyusa amathuba ethu okuthatha inxaxheba kwakhona kwixa elizayo. Impembelelo ye-THC kwinkqubo yomvuzo wobuchopho yeyona nto iphambili kubuchule be-cannabis ukuvelisa iimvakalelo zokunxila kunye nokonwaba.
Yintoni eyenziwa yi-CBD
I-THC ikude neyona nto kuphela kwi-cannabis enempembelelo ngqo ekusebenzeni kwengqondo. Uthelekiso oluphawulekayo lune-cannabidiol (CBD), eyesibini ininzi i-cannabinoid efumaneka kwisityalo se-cannabis. I-CBD ihlala ichazwa njenge-non-psychoactive kodwa oku kuyalahlekisa kuba nayiphi na into enefuthe elithe ngqo kumsebenzi wobuchopho i-psychoactive. I-CBD ngokuqinisekileyo idala iziphumo ze-psychoactive xa inxibelelana nengqondo kunye nenkqubo ye-nervous ephakathi, njengoko kuxelwe ukuba inamandla kakhulu okuchasa ukuxhuzula kunye neepropathi zokulwa nokuxhalaba.
Ke ngelixa i-CBD iyasebenza ngokwengqondo, ayinxilisi. Oko kukuthi, ayikufumani phezulu. Kungenxa yokuba i-CBD imbi kakhulu ekusebenziseni i-CB1 receptor. Enyanisweni, ubungqina bubonisa ukuba ngokwenene kuphazamisa umsebenzi we-CB1 receptor, ngakumbi phambi kwe-THC. Xa i-THC kunye ne-CBD zisebenza kunye ukuchaphazela umsebenzi we-CB1 we-receptor, abasebenzisi bavame ukuziva bethambile, bephezulu kwaye banethuba eliphantsi kakhulu lokufumana i-paranoia xa kuthelekiswa nemiphumo evakalelwa xa i-CBD ingekho. Kungenxa yokuba i-THC yenza i-CB1 receptor isebenze, ngelixa i-CBD iyayinqanda.
I-CBD kunye ne-THC zisebenzisana njani
Ngamafutshane, i-CBD inokukhusela ngokuchasene nokuphazamiseka kwengqondo okunxulumene nokuvezwa kakhulu kwi-THC. Uphononongo luka-2013 olupapashwe kwiJenali ye-Psychopharmacology elawula i-THC kubathathi-nxaxheba kwaye yafumanisa ukuba abo banikwe i-CBD ngaphambi kokulawulwa kwe-THC babonise ukukhubazeka kwememori engaphantsi kwe-episodic kunezigulane ezinikwe indawo ye-placebo - ebonisa ngakumbi ukuba i-CBD inokuthintela i-THC-indutive cognitive. iintsilelo.
Ngapha koko, uphononongo luka-2013 lwezifundo eziphantse zibe li-1,300 ezipapashwe kwiijenali zesayensi zafumanisa ukuba "i-CBD inokuchasana neziphumo ezibi zeTHC." Uphononongo lukwabonisa imfuneko yophando olungakumbi kunye nokujonga iziphumo ze-CBD kusetyenziso lwe-THC kwiimeko zehlabathi lokwenyani. Kodwa idatha ekhoyo icacile ngokwaneleyo ukuba i-CBD ihlala icetyiswa njenge-antidote kwabo baye batya kakhulu i-THC ngokungazi kwaye bazifumane besongamele.
I-Cannabinoids isebenzisana neenkqubo ezininzi emzimbeni
I-THC kunye ne-CBD zibophelela kwezinye iithagethi ezininzi emzimbeni. I-CBD, umzekelo, ineendawo ze-12 zesenzo kwingqondo. Kwaye apho i-CBD inokulinganisa iziphumo ze-THC ngokuthintela i-CB1 receptors, inokuba nezinye iziphumo kwi-THC metabolism kwiindawo ezahlukeneyo zesenzo.
Ngenxa yoko, i-CBD ayinakuhlala ithintela okanye ilinganisela iziphumo ze-THC. Isenokuphucula ngokuthe ngqo iinzuzo zonyango ezinokubakho ze-THC. I-CBD inokuthi, umzekelo, iphucule i-THC-induced pain. I-THC inokuba yinto echasene nokudumba kunye ne-neuroprotective antioxidant, ubukhulu becala ngenxa yokusebenza kwayo kwe-CB1 receptors kwindawo yokulawula intlungu yengqondo.
Uphononongo olusuka kwi-2012 lubonise ukuba i-CBD isebenzisana ne-alpha-3 (α3) i-glycine receptors, eyona nto ibalulekileyo ekujoliswe kuyo ekuqhubeni intlungu kumqolo, ukucinezela intlungu engapheliyo kunye nokuvutha. Ngumzekelo wento ebizwa ngokuba yi-entourage effect, apho iikhompawundi ezahlukeneyo ze-cannabis zisebenza kunye ngokubanzi ukuvelisa isiphumo esikhulu kunokuba sisetyenziswe ngokwahlukeneyo.
Kodwa nolu nxibelelwano alucacanga ngokupheleleyo. Kuphononongo lukaFebruwari 2019, abaphandi bafumanisa ukuba iidosi eziphantsi ze-CBD ngokwenene zonyusa iziphumo ezinxilisayo ze-THC, ngelixa iidosi eziphezulu ze-CBD zinciphisa iziphumo ezinxilisayo ze-THC.
Terpenes kunye nempembelelo yokukhuthaza
Kunokwenzeka ngokupheleleyo ukuba ezinye zeziphumo ezibi ezaziwayo ze-cannabis (ezifana ne-couch-lock) zinokuthi zinento encinci yokwenza ne-THC ngokwayo, kodwa endaweni yoko, iminikelo ehambelanayo yeemolekyuli ezingaziwayo. Iikhompawundi zemichiza ezibizwa ngokuba yi-terpenes zinika izityalo ze-cannabis incasa yazo ekhethekileyo kunye namavumba. Zifumaneka kwizityalo ezininzi - njenge lavender, ixolo lomthi, kunye neehops - kwaye zibonelela ngevumba leoyile efunekayo. I-Terpenes, elona qela likhulu leephytochemicals ezaziwayo kwi-cannabis, nazo zibonakalise ukuba yinxalenye ebalulekileyo yempembelelo ye-entourage. I-terpenes ayinikeli i-cannabis incasa eyahlukileyo kunye nevumba elimnandi, kodwa ibonakala ngathi ixhasa ezinye iimolekyuli ze-cannabis ekuveliseni iziphumo ze-physiological and cerebral.
Okukwintsusa
I-Cannabis sisityalo esintsonkothileyo esinophando oluncinci olufumanekayo kwiziphumo zalo kunye nokusebenzisana nomzimba womntu - kwaye siqala ukufunda iindlela ezininzi iTHC, iCBD, kunye nezinye iikhompawundi ze-cannabis ezisebenza kunye kunye nokusebenzisana ne-ECS yethu ukutshintsha i-cannabis. indlela esiziva ngayo.
Ixesha lokuposa: Oct-19-2021